"Artists try to create their surroundings to make the universe fit what they think it should be," Steven Cerio says. Cerio studied art in his hometown at Syracuse University, then moved to New York City in 1988. His first job was at Psychedelic Solution, a gallery at the center of Greenwich Village. There he encountered Robert Crumb, whose comment on Steven's work was “Hey Cerio, you think you’re going to make a fucking living drawing like this?” Steven responded by pursuing illustration work. His first job was "a woman with six tits and fangs” for Screw magazine. He soon worked for other publications including The Village Voice, Entertainment Weekly and Guitar World, and his art is now shown in galleries nationwide.

Steven's first full-length comic book, PIE, came out in 1996. Steven Cerio's ABC Book – A Drug Primer was published in 1998, and he continues to do commercial work for clients including Nickelodeon.

Steven is also a drummer for his musical project, Lettuce Little, and he has long been involved artistically with legendary San Francisco group The Residents.